Progress in dogs
ENDSULIN has begun a pilot study in naturally diabetic companion dogs. We are the only group in the world testing gene therapy in large mammals for diabetes with an autoimmune disease.
Dogs are the Ideal preclinical model, because they are the largest animal model with autoimmune diabetes, and the etiology is nearly identical to human type 1 diabetes.
Running the trials in naturally diabetic family dogs rather than only lab-induced canines also allows us to observe the treatment’s effects in a much more realistic situation.